Two postdoctoral positions are available in the Laboratory of Dr. David Brooks in the Tumor Immunotherapy Program, Princess Margaret Cancer Center in Toronto, Ontario Canada. Our lab is interested to understand how interferons positively and negatively regulate the immune system to alter tumor control and response to immunotherapy (Snell et al., Trends Immunology 2017 DOI: 10.1016/j.it.2017.05.005; Boukhaled et al., Ann Review Pathology 2022 DOI: 10.1146/annurev-pathol-031920-093932).
Postdoctoral fellows will explore topics related to (1) how interferon regulatory factors direct the pro-inflammatory versus suppressive immune programs to differentially regulate the anti-tumor and/or anti-viral immune response; (2) how interferons contribute to acquired therapy resistance; and (3) further explore how interferon responsive states predict response to immunotherapy. These projects will implement cutting-edge technologies, including CyTOF, multi-omic single-cell RNA and epigenetic sequencing, and spatial analysis to continue uncovering the inflammatory mechanisms regulating anti-tumor and anti-viral immunity.
• A background in cellular and/or molecular immunology.
• Ph.D. applicant near graduating or having recently earned Ph.D.
• High motivation and a strong record of scientific accomplishments, including publications in peer-reviewed journals and scientific presentations.
• Have experience using bioinformatic tools (e.g., UMAP, Phenograph, statistical modeling, Seurat) for performing CyTOF or high-dimensional flow cytometry analysis, and single cell sequencing.
Our group offers a highly collaborative environment to learn and grow into successful independent scientists and leaders. The position provides competitive salary in a well-funded environment.
Salary: Highly competitive salary
Please respond by email to email@example.com, including your CV and description of your experience relevant for this position.
David G. Brooks, PhD
Lab Website: http://www.uhnresearch.ca/researcher/david-brooks
The Princess Margaret Cancer Center (PMCC) is one of the worlds’ largest cancer facilities. It is located in the heart of the vibrant and diverse city of Toronto, Canada. Through its commitment to research, education and innovation, PMCC stands on the frontiers of medical and experimental oncology. The scientific excellence of its internationally recognized researchers, clinicians and cutting-edge translational infrastructure rank the PMCC amongst the top five cancer centers in the world.