Dr. Cynthia Guidos is seeking a Post-Doctoral Fellow to study T cells generated during infancy in her laboratory at the Hospital for Sick Children (SickKids) Research Institute (Toronto, Canada). The successful candidate will develop and implement multiple approaches to define molecular mechanisms and micro-environmental drivers of emergence, self-renewal and functional programming of specialized innate effector-memory T cells in neonatal mice and humans. You will also establish preclinical models to characterize innate effector-memory T cell function in neonatal immune responses to clinically important parasites. This project offers an exciting opportunity to combine traditional cellular and molecular immunology with the power of systems immunology and novel single cell platforms including mass cytometry (CyTOF), single cell sequencing (scRNAseq) and multiplexed tissue imaging (Hyperion) to address key gaps in knowledge of newborn immunity. Thus, this project will provide rich opportunities to develop projects to accelerate your career development trajectory.
The ideal candidates are highly motivated individuals with a recent Ph.D. in Immunology, Developmental Biology or related fields, strong publication records and significant experience with high parameter flow or mass cytometry, single cell or bulk RNA-sequencing, TCR repertoire analysis and/or multi-plexed tissue imaging. Other key assets are strong organizational and communication skills, self-motivation, ability to code in R or Python and the ability to thrive in a highly collaborative and fast paced biomedical research environment. Selected candidates will be asked to provide three references and to participate in a Skype interview.
Applicants should email their CV and a statement of research experience, career goals and motivation for applying to Cynthia.firstname.lastname@example.org. Please reference Post-doctoral Position #12044 in the Subject line
Dedicated exclusively to children and their families, SickKids is one of the largest and most respected paediatric healthcare centres in the world and is located in Toronto’s renowned “Discovery District” – two square kilometers in the heart of downtown Toronto within the city’s centre of innovation. Affiliated with the University of Toronto, we provide an outstanding multi-disciplinary training environment in a premier biomedical research institution that integrates healthcare, leading-edge research and education.
The SickKids Research Institute is committed to ongoing learning and development and features a caring and supportive training environment with state-of-the-art research core facilities as well as competitive salary and excellent benefits to postdoctoral fellows.