Graduate studies or postdoctoral training in neuroimmunology
We are looking for an enthusiastic, hard working, highly motivated, rigorous, and interactive person with strong interest in neuroimmunology and the following qualifications:
• Degree (B.Sc., M.Sc., Ph.D.) in a relevant discipline
• Knowledge in immunology
• Good academic record
• Good writing skills
• Advantages: scientific publications and communications
Luc Vallieres, Ph.D., Professor
Department of Molecular Medicine, Faculty of Medicine, Laval University
Neuroscience Unit, Laval University Hospital Research Center
2705 Laurier Boulevard, Quebec City, Quebec, Canada, G1V 4G2
Characterization of a novel dendritic cell-specific protein in demyelinating autoimmune diseases
Dendritic cells (DCs) orchestrate the activity of T cells, which play a central role in MS. A major challenge in the field is to discover DC-specific molecules that would allow to identify and target DCs with accuracy and that would help to explain their unique properties. We have recently found a novel cell-surface protein of unknown function that is exclusively produced by DCs in a mouse model of MS. The goal of this project is to clarify the function of that protein, while exploiting it as a tool to better understand DCs and autoimmune demyelination. This project will provide fundamental, applicable and patentable knowledge about that protein as well as valuable tools for future studies.
We use a variety of approaches, including mouse models of multiple sclerosis, genome editing using CRISPR-CAS9, single-cell RNA sequencing, mass and flow cytometry, confocal and super- resolution (STED) microscopy, stereology, immunohistochemistry, RNAscope, in situ hybridization, cell culture, recombinant DNA techniques, DNA microarray, RNA interference, lentiviral transduction, quantitative real-time PCR, Western blotting, ELISA, intracranial surgery on mice, and cell transplantation.
Multiple Sclerosis Society of Canada