Graduate studies or postdoctoral training in neuroimmunology
We are looking for an enthusiastic, hard working, highly motivated, rigorous, and interactive person with strong interest in neuroimmunology and the following qualifications:
• Degree (B.Sc., M.Sc., Ph.D.) in a relevant discipline
• Knowledge in immunology
• Good academic record
• Good writing skills
• Advantages: scientific publications and communications
Luc Vallieres, Ph.D., ProfessorDepartment of Molecular Medicine, Faculty of Medicine, Laval UniversityNeuroscience Unit, Laval University Hospital Research Center2705 Laurier Boulevard, Quebec City, Quebec, Canada, G1V 4G2E-mail: Luc.Vallieres@crchul.ulaval.ca
Characterization of regulatory B cells in a new model for multiple sclerosis
B cells contribute to multiple sclerosis (MS); depleting them improves clinical outcomes. However, current drugs deplete most B cells, including regulatory B cells (Bregs) with beneficial anti-inflammatory properties. Studying Bregs could lead to more specific and safer therapies. Recently, we found a population of Bregs in a new mouse model of MS. In this project, our goal is to determine the nature, anatomical distribution and function of these Bregs. This project will help not only to understand these cells, but also to identify new biomarkers and therapeutic strategies for autoimmune diseases like MS.
We use a variety of approaches, including mouse models of multiple sclerosis, genome editing using CRISPR-CAS9, single-cell RNA sequencing, mass and flow cytometry, confocal and super- resolution (STED) microscopy, stereology, immunohistochemistry, RNAscope, in situ hybridization, cell culture, recombinant DNA techniques, DNA microarray, RNA interference, lentiviral transduction, quantitative real-time PCR, Western blotting, ELISA, intracranial surgery on mice, and cell transplantation.
Canadian Institutes of Health Research