A postdoctoral position is available in the Laboratory of Dr. Angela M. Crawley at the Ottawa Hospital Research Institute (OHRI), starting as soon as possible. The postdoctoral fellow will be a part of the Ottawa Viral and Metabolic Liver Disease Research Group at The Ottawa Hospital and affiliated with the University of Ottawa Department of Biochemistry, Microbiology, and Immunology and the Center for Infection, Immunity, and Inflammation at the University of Ottawa (Ottawa, Ontario, CANADA)
The fellow will work to understand the immunological and metabolic mechanisms underlying CD8+ T-cell and/or macrophage dysfunction in chronic liver diseases with advanced liver fibrosis. The research is focused on chronic hepatitis C virus (HCV) infection and metabolic-associated fatty liver disease (MAFLD) in humans. This project will take advantage of approaches we have developed to conduct research using human primary cells and animal models of liver disease. Specifically, we aim to understand the mechanisms underlying lasting immune cell dysfunction in individuals with advanced liver fibrosis. This research hopes to uncover targets for immune restoration to reduce negative clinical outcomes such as impaired responses to infection and liver cancer as well as poor responses to vaccination and immunotherapy. The postdoc will work as part of a dynamic and motivated laboratory team investigating immune dysfunction in chronic liver disease.
To be considered, the Candidate must have a strong background in molecular or cellular immunology, with a proven track-record of success in the immunology research.
Applicants can include those near-graduating from a PhD program, recently awarded a PhD or MD/PhD degree within the last year or who have a maximum of 4 yrs postdoctoral research experience since the date of earning the PhD.
Candidates must be highly motivated, possess excellent communication skills, detail-oriented and organized, and a strong record of scientific accomplishments, including publications in peer-reviewed journals and scientific presentations.
Salary: Highly competitive
Applicants should respond by email to Heidi Hickey (firstname.lastname@example.org) with (1) a curriculum vitae and (2) a brief description of research interests.
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