Job Board > Graduate student - Cancer Immunology and Biophotonics - Université de Sherbrooke Cancer Research Institute (IRCUS)
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Adoptive T cell therapies (ACT) rely on promoting the tumor-killing capacity of a cancer patient’s T cells. These therapies are revolutionizing cancer treatment and have demonstrated remarkable efficiency for some cancer types. However, their effectiveness is still limited; a restricted number of patients with advanced or metastatic cancers benefit from these state-of-the-art therapies, and significant efforts are being made to refine current protocols and develop novel ACT strategies.
Dr. This’s expertise combines high-throughput cellular imaging, computer-assisted image analysis, artificial intelligence approaches as well as biophysical technologies for the manipulation of immune cells. The laboratory is particularly interested in T lymphocytes, with a central question: can their ability to eliminate tumor cells be predicted based on the dynamic analysis of their intracellular signaling? Focusing on the dynamics of T cell receptor (TCR) signaling, using imaging, artificial intelligence, and T cell functionality assays, we propose to identify patients who are most likely to benefit from ACT and improve the efficacy of these treatments. We hypothesize that studying the heterogeneity of TCR signaling dynamics during T cell activation can be valuable to predict T cell states at the single cell level.
Further information about the ongoing research projects is available on the lab website: www.sthis-lab.ca
The lab is looking to recruit 1 or 2 graduate students to undertake various projects currently available in the lab. Previous experience in cell biology, immunology, molecular biology, engineering or bioinformatics is considered an asset but not required. We are looking for curious and motivated students who are open to multidisciplinary learning and eager to develop new scientific skills. We strongly encourage applications from all qualified candidates, including those from marginalized communities, such as Black, Indigenous, and People of Color (BIPOC), 2SLGBTQIA+ individuals, and persons with disabilities.
Sébastien This, PhD (he/him | il)
Professeur-chercheur | Assistant Professor
Institut de recherche sur le cancer de l’Université de Sherbrooke (IRCUS)
3201, Jean-Mignault
Sherbrooke, QC, J1E 4K8
Université de Sherbrooke
Immunologie et Biologie Cellulaire
(819) 821-8000 x72068 | bureau Z8-2057
sebastien.this@usherbrooke.ca
www.sthis-lab.ca
