A highly motivated Postdoctoral fellow and research techinician are being sought to join the Auer Translational Research Lab at the Ottawa Hospital Research Institute to investigate the efficacy of novel immunotherapeutic strategies targeting immune dysfunction in abdominal cancers.
Research Program Overview:
An improved understanding of the immune systems role in combating cancer has resulted in the development of a number of clinically effective therapeutics. However, ongoing large-scale whole genome sequencing efforts continue to reveal the incredible genetic diversity present in patient tumours suggesting that personalized vaccine strategies aimed at enhancing immune recognition of patient-specific neoantigens may offer the best way forward. Dr Rebecca Auer’s research group is currently developing an autologous infected cell vaccine platform for the treatment of abdominal malignancies. Candidates are being sought to continue the preclinical development of this approach which combines the potent immune stimulating properties of oncolytic virus delivery with patient specific antigens to overcome the immunosuppressive tumour microenvironment and promote effective anti-tumour immune responses.
As a clinician-scientist currently leading several clinical trials, Dr Auer has a proven ability to translate findings from the bench to the bedside and is committed to improving outcomes for cancer patients and their families.
For PDF applicants:
• PhD degree awarded within the past 1-2 years
• Demonstrated experience working with animal models of cancer
• A strong understanding of cancer immunology represented by a track record of presenting and publishing research findings
• Previous experience with multi-colour flow cytometry and immune cell isolation
• A desire to work as a member of a team and to supervise junior research staff
Michael Kennedy, PhD