Description: The Department of Immunology in the Faculty of Medicine, University of Toronto, invites applications for the position of Research Associate (Limited Term) for a neuroimmunologist with experience in immune and neurodegenerative aspects of multiple sclerosis (MS) pathology, particularly those which are relevant to cortical demyelination and cognitive impairment driven by complement activation in the central nervous system (CNS). The successful candidate will be responsible for conducting the molecular and neuropathological analysis of post-mortem human MS brain, performing analysis of complement activation/deposition in the CNS and executing prophylactic and therapeutic pre-clinical trials as well as functional studies in animal models of MS-like disease such as experimental autoimmune encephalomyelitis (EAE).
Conduct the molecular (western blot, qPCR) and pathological analysis (immunohistochemistry, immunofluorescence, advanced imaging techniques) of post-mortem MS brain, with focus on cortical demyelination and neurodegeneration;
Test novel therapeutics in EAE;
Monitor clinical disability in EAE;
Perform the immunopathological and neuropathological analysis of mouse brain tissue, including sample collection and preparation, histology/immunohistochemistry (frozen tissue, formalin-fixed paraffin-embedded tissue, resin-embedded tissue), microscopy (light, fluorescence, confocal), data analysis;
Designing, planning and executing research projects;
Supervising other research staff;
Working with multi-disciplinary, multi-institutional teams;
Presenting research findings to PI’s and other members of the research team;
Conducting data analysis and reporting;
Ensuring project goals are met within the context of the larger program;
Liaising with collaborators and assisting in the compilation, analysis and reporting of research findings to researchers within and outside of the program.
Beyond these responsibilities, the individual is expected to participate in the preparation of grant applications. At all times, the individual is expected to support the overall research and teaching missions of the lab. Incumbent will be expected to perform research with a high degree of independence and will design, direct, execute, analyze and present in written and oral forms novel investigative studies that build on and/or take advantage of the resources and expertise within the lab as well as incumbent’s academic expertise.
Qualifications include a Ph.D. in a relevant scientific field with at least 5 years of postdoctoral experience and a strong publication record, including senior (last) authorships. Experience with the analysis of post-mortem human brain tissue, specifically brains from MS donors, is expected. Due to the focus on cognitive impairment in MS, expertise with the immunopathology and neuropathology of the MS hippocampus is imperative, as well as an advanced knowledge of complement biology and relevant complement immunoassays. Brain banking experience will be an advantage. Skills in the induction and clinical monitoring of the EAE model are required. Mastery of experimental models of nerve\brain trauma, which share key aspects of neuronal damage with MS pathology, is an asset. Surgical skills (e.g. implantation of osmotic pumps, perfusion), preparation of brain tissue for histology, experience with the immunopathology and neuropathology of the nervous system, mastery of immunohistochemical techniques, microscopy and experience with software for the analysis of the staining are a requirement.
The incumbent must also show evidence of his/her ability to develop an independent research program with translational value and to independently direct projects. The successful candidate will be expected to contribute to the guidance of technicians and trainees as well as participate in the teaching mission of the lab, and should therefore have previous supervisory and teaching experience. Experience preparing manuscripts for submission to peer-review publications/journals and presenting findings at local, national and international conferences is also required.
Notes: This is a two-year term position.
The University of Toronto is strongly committed to diversity with its community and especially welcomes applications from visible minority group members, women, Aboriginal persons, persons with disabilities, members of sexual minority groups, and others who may contribute to further diversification of ideas.
All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority.
Employee Group: Research Associate, Limited Term
Appointment Type: Grant - Term
Pay Scale Group and Hiring Rate: R01 -- Research Associates (Limited Term): $42,264 - $79,245
Job Field: Research Associate (Limited Term)
Job Posting: Jun 28, 2017
Job Closing: Jul 28, 2017, 11:59:00 PM
Salary: R01 -- Research Associates (Limited Term): $42,264 - $79,245
Apply online: https://utoronto.taleo.net/careersection/10000/jobdetail.ftl?job=1701116